In this free webinar sponsored by Advanced Instruments, gain insights into advances in monoclonal antibody production technology and manufacturing strategies. Attendees will learn why temperature and osmolality in cell culture are critical parameters affecting cell growth, viability and the concentration of HCPs in the supernatant. The featured speaker will discuss how temperature and osmolality in the cell culture can be optimized, seeking improved monoclonal antibody production efficiency.
TORONTO, Jan. 18, 2024 /PRNewswire-PRWeb/ — Over the past two decades, the biopharmaceutical market has expanded, with monoclonal antibodies exhibiting a 26 percent higher approval rate than other drugs. The market value of monoclonal antibodies alone is expected to reach more than $300 billion USD by 2025. Monoclonal antibodies are recombinant proteins that are extracellularly secreted by mammalian cells, such as Chinese hamster ovary (CHO) cells. Advances in monoclonal antibody production technology and manufacturing strategies have led to increased yield, which is, however, accompanied by increased levels of impurities, such as host cell proteins (HCPs).
HCPs are native proteins of CHO cells released in the cell culture supernatant through secretion or cell lysis upon death. Several factors, such as cell line, cell culture media components and operating parameters, have been reported to influence the generation and composition of HCPs in the supernatant. Among these, culture temperature, osmolality, pH and dissolved oxygen tension can directly affect cellular behavior, culture viability and, in turn, HCP accumulation.
Temperature plays an important role in cell culture and can affect cell growth and cell viability. Meanwhile, osmolality, which generally indicates the osmotic pressure condition in the cell culture, has a significant impact on cell growth and metabolism. Studies have reported that manipulating these two parameters independently could have a direct effect on the concentration of the HCPs in the supernatant.
Join this webinar to investigate the effects of simultaneously adjusting temperature and osmolality on the generation of HCPs, antibody yield and cell growth. Join Syazana Mohamad Pauzi, Research Scientist, Imperial College of London, for the live webinar on Thursday, February 8, 2024, at 11am EST (4pm GMT/UK).
For more information, or to register for this event, visit Optimizing Monoclonal Antibody Production: Temperature and Osmolality’s Impact.
ABOUT ADVANCED INSTRUMENTS
Advanced Instruments is a global provider of scientific and analytical instruments for the bioprocessing, clinical and food and beverage industries. The company’s innovations have helped organizations improve quality of results, achieve reliable outcomes, and increase workplace productivity for more than 65 years. In the biopharma space, its Solentim portfolio of best-in-class imaging and single-cell deposition technologies enable the clonal isolation, outgrowth, and characterization of the highest value cells for monoclonal antibody upstream development and cell and gene therapy. Its OsmoTECH® line of micro-osmometers are built specifically to support workflows throughout every phase of bioprocessing. Its Artel portfolio includes leading analytical instruments, software and services that validate, automate, and calibrate critical liquid handling processes and instrumentation. Similarly, clinical labs worldwide rely on Advanced Instruments’ innovative solutions for delivery of accurate and timely patient results in their clinical chemistry, microbiology, and hematology labs. For more information, visit http://www.aicompanies.com
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