Reducing cell line development timelines and resources is a key goal in the generation of biomanufacturing cell lines. In traditional cell line development workflows, hundreds, or even thousands of clones are scaled up to large static or shaken culture volumes so that accurate cell counts and recombinant protein titer measurements can obtained. Not only does the scale up of these large quantities of clones require a significant amount of time, but it is also very resource heavy, often typically requiring multiple personnel and a significant amount of laboratory space. In this study, we employed the Solentim Cell Metric® imaging technology in our cell line development workflow with the aim of reducing development timelines and resources by earlier identification of lead producing recombinant clones.
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